Opponent: Louisville
| H/A/N | Games | Wins | Losses | % |
| All Games | 13 | 10 | 3 | .769 |
| Home | 8 | 6 | 2 | .750 |
| Away | 5 | 4 | 1 | .800 |
HomeAway
Displaying 1-13 of 13 results.
| Season | Date | Rank | Opponent | Opp. Rank | Site | H/A | OTs | WVU | Opp | W/L | Attendance |
| 2011 | November 5, 2011 | 24 | Louisville | | Milan Puskar Stadium | H | | 35 | 38 | L | 57,287 |
| 2010 | November 20, 2010 | | Louisville | | Papa John's Cardinal | A | | 17 | 10 | W | 51,772 |
| 2009 | November 7, 2009 | | Louisville | | Milan Puskar Stadium | H | | 17 | 9 | W | 55,334 |
| 2008 | November 22, 2008 | | Louisville | | PAPA JOHN'S CARDINAL | A | | 35 | 21 | W | 34,796 |
| 2007 | November 8, 2007 | 6 | Louisville | | Milan Puskar Stadium | H | | 38 | 31 | W | 60,992 |
| 2006 | November 2, 2006 | 3 | Louisville | 5 | Papa John's Cardinal | A | | 34 | 44 | L | 43,217 |
| 2005 | October 15, 2005 | | Louisville | 19 | Milan Puskar Stadium | H | 3 | 46 | 44 | W | 59,797 |
| 1993 | October 9, 1993 | 24 | Louisville | 17 | Milan Puskar Stadium | H | | 36 | 34 | W | 57,578 |
| 1990 | September 22, 1990 | | Louisville | | Milan Puskar Stadium | H | | 7 | 9 | L | 61,933 |
| 1989 | September 23, 1989 | 9 | Louisville | | Cardinal Stadium | A | | 30 | 21 | W | 39,132 |
| 1986 | November 15, 1986 | | Louisville | | Cardinal Stadium | A | | 42 | 19 | W | 21,834 |
| 1985 | September 7, 1985 | | Louisville | | Milan Puskar Stadium | H | | 52 | 13 | W | 62,128 |
| 1984 | September 8, 1984 | | Louisville | | Milan Puskar Stadium | H | | 30 | 6 | W | 55,002 |
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